Estimation of population heterozygosity and library construction-induced mutation rate from expressed sequence tag collections.
نویسندگان
چکیده
Unigene alignments obtained from cDNA libraries made using multiple individuals are not currently used to estimate population heterozygosity, as they are known to harbor mutations created during library construction. We describe an estimator of population heterozygosity that utilizes only SNPs unlikely to be library construction artifacts.
منابع مشابه
library construction induced mutation rate from expressed sequence tag collections
Estimation of population heterozygosity and library construction induced mutation rate from expressed sequence tag collections. Abstract: Unigene alignments obtained from cDNA libraries made using multiple individuals are not currently used to estimate population heterozygosity, as they are known to harbor mutations created during library construction. We describe an estimator of population het...
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عنوان ژورنال:
- Genetics
دوره 176 1 شماره
صفحات -
تاریخ انتشار 2007